“Scream 6” is the latest installment in the “Scream” horror franchise, directed by Matt Bettinelli-Olpin and Tyler Gillett of Radio Silence. The film, which releases nationwide on March 10, follows the core cast of 2022’s “Scream” as they attend college in New York City — with the villainous Ghostface in pursuit. Jenna Ortega, Melissa Barrera, Jasmin Savoy Brown, Mason Gooding and Courteney Cox reprise their original roles from the film, with Hayden Panettiere returning to the franchise 12 years since her appearance in “Scream 4.” The movie, which also stars Dermot Mulroney, Samara Weaving and Henry Czerny, is the first “Scream” installment without lead star Neve Campbell.